周扬 
周扬
中国科学院宁波材料技术与工程研究所 副研究员
教育经历：
2008.9-2013.6，博士（Ph.D.），南京大学（985 双一流），生物学 导师：赵劲教授
2004.9-2008.6，学士（B.S.），中国药科大学（211 双一流），药剂学
工作经历：
2017.11–今，中国科学院宁波材料技术与工程研究所 副研究员
2014.5–2015.4，南京大学（985 双一流） 博士后 导师：朱海亮教授
2014.5–2015.4，韩国国立蔚山科学技术大学多维碳材料中心（IBS-CMCM）博士后 导师：Christopher W. Bielawski教授
科研项目：
【1】主持：宁波市青年科技创新领军人才项目，项目名称：以“杀菌-释菌”策略构建的替格瑞洛类FabH抑制剂及其抗菌机理研究，项目经费：30万，起止时间：2024.1-2025.12。
【2】主持：宁波市“科技创新 2025”重大专项，项目名称：基于β-酮酰-ACP缩合酶的新型多靶点抗菌药物开发，项目经费：200万，起止时间：2020.9-2024.8。
【3】主持：国家青年基金，项目名称：基于β-酮酰-ACP缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究，项目经费：24万，起止时间：2021.1-2023.12。
【4】主持：浙江省青年基金，项目名称：新型硫脲-醚甜菜碱两性离子水凝胶的合成、力学性能、自愈性能及抗粘附性研究，项目经费：10万，起止时间：2019.1-2022.12。
【5】主持：深圳湾实验室坪山生物医药研发转化中心2023年度基于新颖分子实体的创新药概念验证项目（重点项目），项目名称：基于 KAS 缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究，项目经费：8万，起止时间：2023.7-2024.6.
【6】主持：宁波市镇海区人民医院产学研项目，项目名称：用于内科胸腔镜下瘘口注射封堵术治疗难治性气胸的生物医用水凝胶研究，项目经费：5万，起止时间：2020.1-2021.12.
【7】主持：中国博士后科学基金第56批面上，项目名称：新型FabH抑制剂的设计，合成及广谱抗菌活性研究，项目经费：5万，起止时间：2014.8-2015.7。
【8】参与：国家重点研发计划-政府间国际科技创新合作重点专项（子课题负责，前三），项目名称：骨诱导及抗菌型超高分子量聚乙烯-多孔钛涂层人工关节关键技术研究，项目经费：94万，起止时间：2020.1-2022.12。
个人学术成绩：
周扬博士长期从事新型药物、医用材料及其生物学效应研究，主要包括新药设计与合成、基于化学蛋白质组学的靶点鉴定、新型生物材料设计合成及其在生 物传感/生物活性物质的定点释放等基础与应用研究，具有药物化学、化学生物学和材料化学等多学科学习和研究背景。独立工作以来，重点围绕“高活性小 分子药物和材料改性”所涉及的重要科学与技术问题开展工作，致力于通过化学方法对分子结构和材料骨架进行精确调控，开发基于靶点结构的高活性抗菌/ 抗癌药物分子以及具有生物活性的凝胶材料，满足凝胶材料力学性能调控与生物医用的多功能需求。迄今已在Angew.Chem. Int. Ed.、Adv. Funct. Mater、 Mater. Horiz.、ACS Appl Mater Interfaces等高水平期刊发表论文40余篇，累计被引用1500余次。先后入选宁波市青年科技创新领军人才、宁波市领军与 拔尖人才工程、宁波市高级人才、慈溪市115人才培养工程等，主持宁波市20205重大专项、国家青年基金、浙江省青年基金、中国博士后面上基金等，近 五年以项目负责人承担纵向项目经费近270万，参与国家科技国家重点研发计划1项。
授权专利：
获得三项中国专利授权，申请一项中国发明专利
【1】周扬、梁寅秋、王昕雨、常皓云、胡素佩，一种酰胺类化合物及其制备方法。授权专利号：ZL202210056304.4。
【2】 张华、周扬、陈静、徐亚文，一种荧光小分子及其制备方法和应用，授权专利：202011347832.2。
【3】周扬、郭帅均、常皓云、王晨旭、江嘉奇，一种两性离子聚合物水凝胶及其制备方法和应用，授权专利：ZL202210153133.7
【4】郭帅均、周扬、仇晓阳、梁寅秋、王欣雨，一种导电水凝胶及其制备方法和应用，专利申请号：202110235741.8。
联系方式：
电话：15867260864 E-mail：zhouyang876@nimte.ac.cn
部分学术论文：
共同一作全部标注#号，通讯作者（包括共同通讯作者）标注*号
[1] Rui-Yin Ji, Hao-Yun Chang, Shao-Peng Yan, Bo-Tao, Zhang, Xiu-Xiu Wang, Yang Zhou*. Ureido-ionic liquid mediated conductive hydrogel: superior integrated properties for advanced biosensing applications. Adv. Sci. 2024, 2401869. (TOP期刊)
[2] Haoyun Chang, Ruiyin Ji, Shaopeng Yan, Peng Huang*, Rui Wang*, Yang Zhou*. Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity. Eur. J. Med. Chem. 2024, 265, 116064. (TOP期刊)
[3] Juan Sun, Qi Zheng, Yi-Heng Zhang, Cai-Shi Liu, Chong-Hao Chen, Shao-Peng Yan, Xiao-Meng Guo, Su-Pei Hu*, Yang Zhou*, Yuan-Feng Wu*. Structure–activity relationship (SAR) of 18β-glycyrrhetinic acid derivatives on their antitumor activity through the PPARγ receptor and caspase-3 pathway. J. Saudi. Chem. Soc. 2024, 28, 101815.
[4] Hui Chen, Jiangpo Ma, Feng Zhou, Junhui Yang, Lei Jiang, Quanbing Chen, Yang Zhou*, Jiantao Zhang*. A potential cocrystal strategy to tailor in-vitro dissolution and improve Caco-2 permeability and oral bioavailability of berberine. Int. J. Pharmaceut. 2024, 666, 124789. (TOP期刊)
[5] Shao-Peng Yan, Zhi-Yu Zhu, Qi-Ke Jia Rui-Ying Ji, Ya-Pin Wang, Dan He, Rong Wang* Xiao-Jun Xu, Yang Zhou*. Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives. Acta Chim. Slov. 2024, 71, 509–518.
[6] Jing Wang, Haiyang Fei, Min Zhou, Chengcai Zhang, Juan Sun*, Yang Zhou*, Meng Yang*. Synthesis, Crystal Structures and Antibacterial Activity of Nickel(II) and Copper(II) Complexes Derived from (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide. Acta Chim. Slov. 2024, 71, 20–25.
[7] Juan Sun*, Ze-Yu Fang, Yi-Nuo Tao, Yi-Heng Zhang, Yao Zhang, Hai-Ya Sun, Yang Zhou*, Yuan-Feng Wu*. Design, synthesis and antitumor activity of FAK/PLK1 dual inhibitors with quinazolinone as the skeleton. Chem. Biodiversity 2023, 20, e202300146.
[8] Juan Sun*, Cui-Ping Zhang, Chong-Hao Chen, Xiao-Meng Guo, Cai-Shi Liu, Yang Zhou*, Fu-Liang Hu*. Design, synthesis and molecular docking of 1,3,4-Oxadiazole-2(3H)-thione derivatives containing 1,4-benzodioxane skeleton as potential FabH inhibitors. Chem. Biodiversity 2023, 20, e202201060.
[9] Hua Wei, Shengkai Yu, Yansheng Zhang, Hua Zhang, Yuxi Ma, Mengjia Xu, Peng An, Yang Zhou, Sami Halila*, Yen Wei*, Jing Chen*. Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair. Carbohyd. Polym. 2023, 313, 120904.
[10] Shuai-Jun Guo, Hao-Yun Chang, Meng-Jia Xu, Chen-Xu Wang, Hua Wei, Dong-Dong Li, Jing Chen*, Yang Zhou*, Yi Liu*. Co2+-mediated hydrogels with enhanced mechanical properties for flexible sensing. ACS Appl. Polym. Mater. 2022，4，6403-6413.
[11] Yang Zhou, Yin-Qiu Liang, Xin-Yu Wang, Hao-Yun Chang, Su-Pei Hu*, Juan Sun*. Design, synthesis and antibacterial activities of novel amide derivatives bearing dioxygenated rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Chem. Pharm. Bull. 2022, 70, 544-549.
[12] Peng An, Hua Wei, Yan-Sheng Zhang, Yang Zhou, Hua Zhang*, Wen-Feng Li, Bao-Long Niu*, Jing Chen*. A mechanically adaptive “all-sugar” hydrogel for cell-laden injection. Eur. Polym. J. 2022, 174, 111328.
[13] Juan Sun*, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo, Yang Zhou*, Yuan-Feng Wu*. Thiazolidinedione: A privileged scaffold for the development of anticancer agents. Curr. Top. Med. Chem. 2021, 21, 2529-2545.
[14] Hua Wei, Zhen-Wu Wang, Hua Zhang, You-Ju Huang*, Zong-Bao Wang, Yang Zhou, Ben-Bin Xu*, Sami Halila, and Jing Chen*. Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogels for multimode tactical sensing. Chem. Mater. 2021, 33, 6731-6742. (TOP期刊)
[15] Hua Zhang, Ting Xu, Dong-Dong Li, Tao Cheng, Jing Chen*, Yang Zhou*. Gold complexes of bis-indazole-derived N-Heterocyclic carbene: synthesis, structural characterizations, and catalysis. J. Mol. Struct. 2021, 1233, 130043.
[16] Amarachi Rosemary Osi, Hua Zhang, Jing Chen, Yang Zhou, Rong Wang, Jun Fu*, Peter Müller-Buschbaum, Qi Zhong. Three-dimensional-printable thermo/photo-cross-linked methacrylated chitosan−gelatin hydrogel composites for tissue engineering. ACS Appl. Mater. Interfaces 2021, 13, 22902-22913. (TOP期刊)
[17] Xin-Jie Pei, Hua Zhang, Yang Zhou, Lin-Jie Zhou and Jun Fu*. Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions. Mater. Horiz. 2020, 7, 1872-1882 (年度杰出论文奖).
[18] Hua Zhang, Yang Cong, Amarachi Rosemary Osi, Yang Zhou, Fang-Cheng Huang, Remo P. Zaccaria, Jing Chen, Rong Wang, and Jun Fu*. Direct 3D printed biomimetic scaffolds based on hydrogel microparticles for cell spheroid growth. Adv. Funct. Mater. 2020, 30, 1910573. (TOP期刊)
[19] Hua Zhang, Peng-Gang Ren, Hua Wei, Sami Halila, Amarachi Osi, Yang Zhou*, Zhong Dai, Rong Wang, Jing Chen*. Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent. Soft Matter 2020,16, 8647-8654.
[20] Hua Zhang, Peng-Gang Ren, Fan Yang, Jing Chen, Chen-Xu Wang, Yang Zhou, Jun Fu*. Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions. J. Mater. Chem. B 2020, 8, 10549-10558.
[21] Hua Wei, Hua Zhang, Yang Zhou*, Zong-Bao Wang, Rong Wang, Jing Chen. Understanding of growth mechanism and structure of multilayer thin films via layer-by-layer hydrogen bonded assembly from polymer brushes-grafted surface. Nanosci. Nanotechnol. Lett. 2020, 12, 890-900.
[22] Kun Fang, Rong Wang*, Hua Zhang, Lin-Jie Zhou, Ting Xu, Ying Xiao, Yang Zhou, Guo-Rong Gao, Jing Chen, Donglei Liu*, Fan-Rong Ai, and Jun Fu*. Mechano-responsive, tough, and antibacterial zwitterionic hydrogels with controllable drug Release for wound healing applications. ACS Appl Mater Interfaces 2020, 12, 52307-52318. (TOP期刊)
[23] Yong Yin†, Yang Zhou†(共同一作), Shao Sha, Xun Wu, She-Feng Wang, Fang Qiao, Zhong-Cheng Song*, Hai-Liang Zhu*. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα. Bioorg. Chem. 2019, 92, 103238. (TOP期刊)
[24] Xu-Ping Zhang, Tian-Tian Wang, Zeng-Hui Yuan, Yang Zhou*, Yu-Shun Yang*, Hai-Liang Zhu*. A quinoxalinone-derivated fluorescence sensor with optimized solubility for cysteine detection and biological imaging. Dyes Pigments 2019, 171, 10771.
[25] Dan Xu, Ting Xu, Guorong Gao, Ying Xiao, Zongbao Wang, Jing Chen, Yang Zhou, Rong Wang, Jingbo Yin, Jun Fu*. Effect of Solvent-Matrix Interactions on Structures and Mechanical Properties of Micelle-Crosslinked Gels. J Polym Sci Part B Polym Phys 2019, 57, 473-483.
[26] Liu-Fang Wang, Guo-Rong Gao, Yang Zhou, Ting Xu, Jing Chen, Rong Wang, Rui Zhang*, Jun Fu*. Tough, adhensive, self-healable and transparent ionically conductive zwitterionic nanocomposite hydrogels as skin strain. ACS Appl Mater Interfaces 2019, 11, 3506-3515. (TOP期刊)
[27] Zhen-Wu Wang, Jing Chen, Liu-Fang wang, Guo-Rong Gao, Yang Zhou, Rong Wang, Ting Xu, Jing-Bo Yin*, Jun Fu*. Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels. J Mater Chem B 2019, 7, 24-29.
[28] Yin Luo*†, Yang Zhou† (共同一作), Yan-Hua Song, Guo Chen, Yu-Xiang Wang, Ye Tian, Wei-Wei Fan, Yu-Shun Yang, Tao Cheng, Hai-Liang Zhu. Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity. Bioorg. Med. Chem. Lett. 2018, 28, 3634-3638.
[29] Guo-Rong Gao, Liu-Fang Wang, Yang Cong, Zhen-Wu Wang, Yang Zhou, Rong Wang, Jing Chen, Jun Fu*. Synergistic pH and temperature driven actuation of poly (NIPAM-co-DMAPMA)/clay nanocomposite hydrogel bilayers. ACS Omega 2018, 3, 17914-17921.
[30] Yang Zhou, Yu-Shun Yang, Xiao-Da Song, Liang Lu, Hai-Liang Zhu*. Study of Schiff-Base-Derived with Dioxygenated Rings and Nitrogen heterocycle as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Chem. Pharm. Bull. 2017, 65, 178-185.
[31] Yang Zhou, Yin Luo, Yu-Shun Yang, Liang Lu, Hai-Liang Zhu*. Study of acylhydrazone derivatives with dioxygenated seven-membered ring as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors. Med. Chem. Commun. 2016, 7, 1980-1987.
[32] Yin Luo†, Yang Zhou† (共同一作), Jie Fu, Hai-Liang Zhu*. 4,5-Dihydropyrazole derivatives containing oxygen-bearing heterocycles as potential telomerase inhibitors with anticancer activity. RSC Adv. 2014, 4, 23904-23913.
[33] Dong-Qi Wang, Sheng Cai, Rong Ben, Yang Zhou, Xing-Wei Li, Jing Zhao, Wei Wei*, Yong Qian*. Direct access to isoindolinone derivatives by palladium-catalyzed C–H activation and isocyanide insertion by using molecular oxygen as the sole Oxidant. Synthesis 2014, 46, 2045-2050.
[34] Yang Zhou, Qing-Jie Liu, Wei-Feng Lv, Qing-Yu Pang, Rong Ben, Yong Qian*, and Jing Zhao*. Indazolin-s-ylidene–N-heterocyclic carbene complexes of rhodium, palladium, and gold: synthesis, characterization, and catalytic hydration of alkynes. Organometallics 2013, 13, 3753-3759.
[35] Yang Zhou, Qian-Ru Du, Jian Sun, Jing-Ran Li, Fei Fang, Dong-Dong Li, Yong Qian, Hai-Bin Gong*, Jing Zhao, and Hai-Liang Zhu*. Novel schiff-base-derived FabH Inhibitors with dioxygenated rings as antibiotic agents. ChemMedChem 2013, 8, 433-441.
[36] Peng-Cheng Lv, Huan-Qiu Li, Juan Sun, Yang Zhou, Hai-Liang Zhu*. Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents. Bioorg. Med. Chem. 2010, 18, 4606-4614.
[37] Kui Cheng, Qing-Zhong Zheng, Jin Hou, Yang Zhou, Chang-Hong Liu*, Jing Zhao*, Hai-Liang Zhu*. Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorg. Med. Chem. 2010, 18, 2447-2455.
[38] Ying Yang, Lei Shi, Yang Zhou, Huan-Qiu Li, Zhen-Wei Zhu, Hai-Liang Zhu*. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg. Med. Chem. Lett. 2010, 20, 6653-6656.
[39] Yin Luo, Huan-Qiu Li, Yang Zhou, Zi-Lin Li, Tao Yan, and Hai-Liang Zhu*. Metronidazole-deoxybenzoin derivatives as anti-helicobacter pylori agents with potent inhibitory activity against HPE-induced interleukin-8. ChemMedChem 2010, 5, 1110-1116.
[40] Yang Zhou, Jing Zhao*, and Lei Liu*. Meta-selective transition metal catalyzed arene C-H bond functionalization. Angew. Chem. Int. Ed. 2009, 48, 7126-7128. (TOP期刊)
[41] Qing-Fu Zeng*, Jie Fu, Yang Zhou, Yin-Tao Shi, Hai-Liang Zhu*. Photooxidation degradation of reactive brilliant red K-2BP in aqueous solution by ultraviolet radiation/sodium hypochlorite. Clean-Soil Air Water 2009, 37, 574-580.